- What is the function of miRNA-489 in cancer? Can it be used as a diagnostic and prognostic tool in tumors? More detail on this topic is available in our paper titled “Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence” which is published in International Journal of Biological Macromolecules (Q1, IF: 6.95).
- Ertaş Lab is awarded a highly competitive TÜBİTAK 1001 grant with the project titled “Development of theranostic anti-ACE2 antibody-coated niosome agent loaded with miR-1275 for targeting and inhibiting the genomic RNA of SARS-CoV-2”.
- Controlled and prolonged oxygen release to bioprinted constructs is essential to keep the tissue alive. Here we explain, summarize and compare the methods of fabricating O2 releasing biomaterials in the paper titled “Methods for fabricating oxygen releasing biomaterials” which is published in Journal of Drug Targeting (Q1, IF: 5.12).
- How can we come up with effective anticancer drugs, and what are the computational techniques for this task? New paper titled “Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds” is published in Frontiers in Pharmacology (Q1, IF: 5.81).
- Why is it so hard to eradicate the cancer? What is a cancer stem cell (CSC) and what role it has in cancer? How can we use nanomaterials to targets CSCs? New paper titled “Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances” is published in Nanomaterials (Q1, IF: 5.08).
- Our cover design for the paper titled “Advances in biomedical applications of self-healing hydrogels” is chosen as the Front Cover of the Materials Chemistry Frontiers for the June issue. The cover image was designed and produced by Ertaş Lab!
- How can a material (hydrogel) self-heal, and what are the biomedical applications of such materials? We published a review paper titled “Advances in biomedical applications of self-healing hydrogels” in Materials Chemistry Frontiers (Q1, IF: 6.79).
- How can biomaterials help us diagnose, prevent, treat, and study the COVID-19? We critically summarized, analyzed and evaluated the field. The paper titled “Role of biomaterials in the diagnosis, prevention, treatment and study of corona virus disease 2019 (COVID-19)” is published in Emergent Materials.
- Dr. Ertaş attends a YouTube live stream hosted by “Gelecek Bilimde” channel and discusses the concept, applications and future of 3D-Bioprinting.
- How can nanotechnology help us fight with COVID-19? We have reviewed the field in a paper titled “Nanotechnology against the novel coronavirus (severe acute respiratory syndrome coronavirus 2): diagnosis, treatment, therapy and future perspectives” which is published in Nanomedicine! (Q1, IF: 4.3)
- Dr. Ertaş attends an invited live TV program and gives a talk on artificial organs.
- Our cover design for the paper titled “3D Bioprinting of Oxygenated Cell‐Laden Gelatin Methacryloyl Constructs” is chosen as the Cover Image of the Advanced Healthcare Materials for the August issue. The cover image was designed and produced by Ertaş Lab!
We present a novel approach to develop oxygenated bioinks, using oxygen generating calcium peroxide particles. Cardiomyocyte‐laden oxygenated and 3D printed tissue constructs developed in this study can significantly support cell survival when applied in hypoxic conditions. They can also be delivered using minimally invasive approach to ischemic hearts.
- Dr. Ertaş is featured in Minister of Industry and Technology Mustafa Varank`s video twit.
- Check out our paper titled “3D Bioprinting of Oxygenated Cell‐Laden Gelatin Methacryloyl Constructs” which is published in Advanced Healthcare Materials! (Q1, IF = 7.4)
Cell survival during the early stages of transplantation and before new blood vessels formation is a major challenge in translational applications of 3D bioprinted tissues. Supplementing oxygen (O2) to transplanted cells via an O2 generating source such as calcium peroxide (CPO) is an attractive approach to ensure cell viability. Calcium peroxide also produces calcium hydroxide that reduces the viscosity of bioinks, which is a limiting factor for bioprinting. In this study, a gelatin methacryloyl (GelMA) bioink that is optimized in terms of pH and viscosity is developed. The improved rheological properties lead to the production of a robust bioink suitable for 3D bioprinting and controlled O2 release. Fibroblasts and cardiomyocytes are bioprinted using CPO containing GelMA bioink. Viability and metabolic activity of printed cells are checked after 7 days of culture under hypoxic condition. The results show that the addition of CPO improves the metabolic activity and viability of cells in bioprinted constructs under hypoxic condition.
- Dr. Ertaş leaves his postdoctoral appointment at University of California, Los Angeles (UCLA) and joins Erciyes University as a TÜBİTAK 2232 fellow.
- Dr. Ertaş receives the prestigious International Fellowship for Outstanding Researchers Program (TÜBİTAK 2232) with a project budget of ~2,920,000 ₺.